Supportive care research from a rehabilitation perspective, focusing on non-pharmacological interventions for chemotherapy-induced peripheral neuropathy

Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect characterized by numbness and tingling in the hands and feet, which occurs after cancer drug treatment. Currently, there are no established treatments or prevention methods for this condition.

To address this, we are advancing research focused on non-pharmacological approaches to alleviate CIPN and are working to disseminate these methods to a larger number of patients. Additionally, we are consolidating evidence related to CIPN.

Related Research Achievements:

• 冷却によるCIPN予防：Hanai A, Ishiguro H, Sozu T, et al. Effects of Cryotherapy on Objective and Subjective Symptoms of Paclitaxel-Induced Neuropathy: Prospective Self-Controlled Trial. J Natl Cancer Inst. 2018;110(2):141-148. doi:10.1093/jnci/djx178
• CIPN軽減のための冷却医療機器開発：Funasaka C, Hanai A, Zenda S, et al. Mitigation of paclitaxel-induced peripheral neuropathy in breast cancer patients using limb-cooling apparatus: a study protocol for a randomized controlled trial. Front Oncol. 2023;13:1216813. Published 2023 Jul 7. doi:10.3389/fonc.2023.1216813
• 診療ガイドライン統括：がん薬物療法に伴う末梢神経障害診療ガイドライン 日本がんサポーティブケア学会　金原出版 2023年6月 (ISBN: 9784307204712)

Research on supporting well-being using AI based on behavioral science

We are researching the use of AI to address the challenges of subjectivity when assessing individual symptoms, and developing foundational LLM models to achieve highly empathetic communication through generative AI.

Related Research Achievements:

• 機械学習手法によるアンケートデータの解析：Hanai A, Ishikawa T, Sugao S, et al. Explainable Machine Learning Classification to Identify Vulnerable Groups Among Parenting Mothers: Web-Based Cross-Sectional Questionnaire Study. JMIR Form Res. 2024;8:e47372. Published 2024 Feb 7. doi:10.2196/47372
• 生成AIによるコミュニケーション上のバイアス：Hanai A, Ishikawa T, Kawauchi S, Iida Y, Kawakami E. Generative artificial intelligence and non-pharmacological bias: an experimental study on cancer patient sexual health communications. BMJ Health Care Inform. 2024;31(1):e100924. Published 2024 Apr 4. doi:10.1136/bmjhci-2023-100924